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I graduated nursing school in August and I'm ready to buy a home. I currently work pool (no guarentee of hours) but I have been getting at the minimum 48hr/pay if not more at $29/hr. Is it possible to get approved or will I have to be full-time before I can apply?
You should be fine as long as you qualify for all requirements.
Nursing field is needed in every state, and very rare to ever find a nurse sitting on unemployment.
You can also apply for per diem work at many hospitals if you are qualified for all licensing requirements.
Since it is your field of study, you do not have to worry about the employment history.