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Toshiba has all these ever-so-helpful spots on the mousepad that, if touched just right, suddenly make your computer start doing something you never intended.
I turned off that "feature" shortly after getting my Toshiba laptop. As for the original poster's question about the mouse, it could be a software or hardware issue with the mouse or with the computer. If OP still doesn't have the problem fixed one of the things to try is plugging that mouse into a different computer to check whether that mouse still works on a different computer. Another thing to try is plugging that mouse into different USB ports on the laptop in question, because sometimes a hardware failure will affect only one USB port.
Many good points previously posted....here is my list (some maybe redundant to other posts).
1. Unplug, then replug mouse.
2. Plug into a different USB.
3. Check batteries (if applicable)
4. Reboot computer
5. Test the mouse on another computer, test a different mouse on the problem computer and compare results
6. Uninstall the mouse and driver
a. go to START -> CONTROL PANEL -> SYSTEM -> HARDWARE -> DEVICE MANAGER
b. find MICE AND OTHER POINTING DEVICES
c. see if your mouse is listed (something like USB MOUSE of PS/2 COMPATIBLE MOUSE)
d. if present, highlight and then select menu option ACTION -> UNINSTALL
e. once uninstalled, unplug mouse
f. reboot
g. plug mouse in (different port) and see if Windows finds and installs the mouse again
On laptops sometimes there is a button or control to turn on and off the touch/glide pad. And sometimes when it is turned on, the mouse won't work.