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Nothing really new about this. This happens with many banks. The pre-screening or pre-q are done by computers. Most of the actual applications are reviewed by humans.
Sorry to hear about the rejection. Pre-quals are never a sure thing, though. You always want to go into any app knowing that.
You said you got the letter saying your EX FICO was 650. That's a pretty borderline score for an Amex approval. What reasons were stated in the letter?
one of the reasons was
Not enough revolving accounts.
(which is 3 revolvers available all zero balances and a Mortgage and a student loan.