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Back in August of last year, I applied for the Bank of America cash rewards card and was offered the 99/500 Cash rewards card instead. I accepted and treated the card like it was a precious gem since I had heard it could unsecure early in some cases. Fast forward to January, and I saw the CLI button on my homepage, so I called them up and asked if I was eligible to unsecure and indeed I was and they gave me a pretty CLI as well. Now, I really kind of like the idea of having a Cincinnati Reds card or the Susan G Komen card, the reward structure is the same, so I didn't know if they might let me change my card design to one of those? It's not that I don't like the Red card I have, but I like the other cards too!
Only way to find out is to call and see what your PC options are. Generally they are fairly flexible with PCs, but they do take 2-3 weeks to process them. You can potentially PC to the Susan G Komen or whatever you prefer.