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With that much equity, it should theoretically be easy to do either, but if your DTI is very high then that could limit the size of the HELOC or the amount of cash you get out in a refinance.
The advantage of a HELOC is that you probably can get one without any closing costs. However, the interest rate is variable and will eventually begin to rise when economy improves and the Fed starts to tighten monetary policy again.
Depending on the need for the money, you will be far better off with a HELOC.
I would suggest looking at other alternatives for your need before going for a HELOC.
I would also recommend that you stay away from refinancing your mortgage unless their is an extreme emergency.